University of Tehran Journal of Mycology Research 2383-3181 2 1 2015 03 01 In vitro antifungal activity of Zataria multiflora essential oil, fluconazole and ciclopirox olamine against nonalbicans Candida species isolated from recurrent vulvovaginal candidiasis 3 8 54153 EN Mohammad Ali Esfandiary Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Shahram Mahmoudi Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Farideh Zaini Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Mahin Safara Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Mahmoud Mahmoudi Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Alireza Farasat Young Researchers & Elite Club, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran Azar Sabokbar Department of Microbiology, Karaj Branch, Islamic Azad University, Karaj, Iran. Sanaz Abbasi Department of Microbiology, Karaj Branch, Islamic Azad University, Karaj, Iran. Mohammad Ghahri Department of Biological Sciences, College of Sciences, Imam Hussein University, Tehran, Iran. Mohammad Amin Esfandiary Faculty of pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Parivash Kordbacheh Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Journal Article 2015 03 25 The aim of the present study was to investigate the antifungal activity of Zataria<br />multiflora essential oil, fluconazole and ciclopirox olamine against 44 non-albicans<br />Candida isolates from patients with recurrent vulvovaginal candidiasis. A set of C.<br />glabrata (29 strains), C. krusei (3 stains) and C. patapsilosis (2 strains) were studied<br />using Clinical and Laboratory Standards Institute (CLSI) broth macrodilution method.<br />The results revealed that 33 isolates were resistant (MIC=64 μg/ml), 4 isolates were<br />susceptible (MIC≤ 8 μg/ml) and 7 isolates had dose-dependent susceptibility (MIC= 16,<br />32 μg/ml) to fluconazole, respectively. With regard to fluconazole, high resistance rate<br />was observed in C .glabrata and C. krusei. However, ciclopirox olamine was found to<br />inhibit the growth of all non-albicans Candida species (MIC≤8 μg/ml). In this study,<br />favorable antifungal activity against non-albicans Candida species was obtained by Z.<br />multiflora despite having a wide range of MICs (34875-139500 μg/ml). The results<br />indicated that ciclopirox olamine and Z. multiflora might be promising in the treatment of<br />recurrent vulvovaginal candidiasis. https://jmr.ut.ac.ir/article_54153_5cc5019b1838069f2a5268300cc0dd7e.pdf