Comparison between Fluconazole and Terbinafine in the treatment of Tinea corporis and Tinea cruris

Document Type : Original Articles


1 Cutaneous Leishmaniasis Research Center, Department of Dermatology, School of Medicine, Mashhad University of Medical Sciences, Mashhad,

2 Departments of Parasitology, School of Medicine, Mashhad University of Medical Sciences, Mashhad,

3 General Physician, Health center, Mashhad University of Medical Sciences, Mashhad, Iran

4 Research Center for HIV/AIDS, HTLV and Viral Hepatitis, Iranian Academic Center for Education, Culture and Research (ACECR), Mashhad, IR Iran.

5 Associated Professor of Microbiology, Antimicrobial Resistance Research Center, Department of Microbiology, School of Medicine,Mashhad University of Medical Sciences, Mashhad, Iran.

6 Parasitology Department, Mashhad University of Medical Sciences, Mashhad, Iran.


Objectives: This study aimed to compare the therapeutic efficacy of Terbinafine and
Fluconazole in terms of mycological cure in the treatment of Tinea corporis and Tinea
cruris. Method: In this clinical trial, 30 patients with T. corporis and T .cruris were
selected. Patients were divided into two groups by random selection. The first group was
treated with Fluconazole 150 mg weekly for four weeks and the second group was
administered Terbinafine 250 mg daily for two weeks. The participants were followed up
till the end of the treatment and one month after treatment. Results: At the end of the
treatment, 64.3% of the subjects in Fluconazole group developed clinical and laboratory
responses; while the second group developed 75% clinical and 81.3% laboratory cure.
One month later, 64.3% in the Fluconazole group were cured, while in the other group,
87.5% were cured. No patient had any side effect. Conclusion: Although, no significant
difference was observed between these two groups of patients in clinical and laboratory
aspect, as a result of lower price and easier consumption, it is suggested that Fluconazole
is more suitable for treatment of Tinea infections.


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